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NAcM-OPT HCl(2089293-61-6 free base)
CAS No. 2416146-10-4
NAcM-OPT HCl(2089293-61-6 free base)( —— )
Catalog No. M24112 CAS No. 2416146-10-4
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 76 | In Stock |
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| 25MG | 136 | In Stock |
|
| 50MG | 227 | In Stock |
|
| 100MG | 371 | In Stock |
|
| 500MG | 879 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNAcM-OPT HCl(2089293-61-6 free base)
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NoteResearch use only, not for human use.
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Brief DescriptionNAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
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DescriptionNAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetNEDD8
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RecptorDCN1-UBE2M
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Research Area——
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Indication——
Chemical Information
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CAS Number2416146-10-4
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Formula Weight470.86
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Molecular FormulaC23H30Cl3N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.
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NAcM-OPT HCl(2089293...
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
-
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